} return true; }
Raffa, R.B., Buschmann, H., Christoph, T., Eichenbaum, G., Englberger, W., Flores, C.M., Hertrampf, T., Kogel, B., Schiene, K., Strassburger, W., Terlinden, R. and Tzschentke, T.M. (2012) Mechanistic and Functional Differentiation of Tapentadol and Tramadol. Expert Opinion on Pharmacotherapy, 13, 1437-1449.
ABSTRACT: The ease of availability and potential tendency to abuse tramadol hydrochloride prompted this research. Making use of biochemical and histological techniques, concentrations of marker enzymes were monitored along with alterations in the liver architecture of wistar albino rats in graded doses of tramadol hydrochloride for 28 days. Specifically, levels of gammaglutamyltransferase (-GT), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. Statistical evaluation of the results at a p