TITLE:
Analysis on Correlation between Resistin—420C/G Polymorphism and Type 2 Diabetes Mellitus Macroangiopathy in Han Population of Northeast China
AUTHORS:
Bingxue Qi, Ma Yan, Yadong Sun
KEYWORDS:
Type 2 Diabetes Mellitus, Resistin, Gene Polymorphism, Macroangiopathy, Polymerase Chain Reaction
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.5 No.12,
November
21,
2017
ABSTRACT:
Objective: To study the allelic and genotypic frequency distribution of RETN—420C/G single nucleotide polymorphisms (SNPs) and its relationship with type 2 diabetes mellitus (T2DM) complicated with macroangiopathy in Han population of northeast China. Methods: The genotypes and their frequencies of a total of 180 cases, including 60 cases of T2DM complicated with macroangiopathy, 60 cases of simple T2DM and 60 cases of normal control (ND), were measured by PCR—RFLP. Results: The allelic frequencies and simple CC/GC + GG genotype in T2DM complicated with macroangiopathy group were significant different compared with ND group (P Conclusion: The RETN—420C/G polymorphism has a correlation with the occurrence of T2DM complicated with macroangiopathy in Han population of northeast China.