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Article citations


Hardy, R., Rabbitt, E.H., Filer, A., Emery, P., Hewison, M., Stewart, P.M., Gittoes, N.J., Buckley, C.D., Raza, K. and Cooper, M.S. (2008) Local and Systemic Glucocorticoid Metabolism in Inflammatory Arthritis. Annals of the Rheumatic Diseases, 67, 1204-1210.

has been cited by the following article:

  • TITLE: Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Experimental Periodontitis Induced by Lipopolysaccharide from Porphyromonas gingivalis

    AUTHORS: Atsuko Fujita, Takaya Nakata, Makoto Umeda, Hiroaki Masuzaki, Hirofumi Sawai

    KEYWORDS: Chronic Periodontitis, 11β-Hydroxysteroid Dehydrogenase Type 1, Lipopolysaccharide, Porphyromonas gingivalis

    JOURNAL NAME: Open Journal of Stomatology, Vol.7 No.10, September 30, 2017

    ABSTRACT: It has been proposed that 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which activates glucocorticoids, plays a role in chronic inflammatory diseases including metabolic diseases, rheumatoid arthritis, and ulcerative colitis. We have recently reported that the expression of 11β-HSD1 is increased in the gingiva of patients with chronic periodontitis and in that of rats with ligature-induced periodontitis. In this study, to further demonstrate the involvement of 11β-HSD1 in chronic periodontitis, the expression of 11β-HSD1 was investigated in another rat model of experimental periodontitis induced by intragingival injection of lipopolysaccharide from Porphyromonas gingivalis (LPS-PG). Alveolar bone loss was observed two weeks after intragingival injection of LPS-PG. The level of 11β-HSD1 mRNA assessed by real-time reverse transcriptase-polymerase chain reaction was significantly elevated in LPS-PG-induced periodontitis compared with controls. The expression of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which inactivates glucocorticoids, was not significantly different between control and LPS-PG-induced periodontitis. The expression of 11β-HSD1 was significantly correlated with that of TNF in LPS-PG-induced periodontitis. The increased expression of 11β-HSD1 protein in LPS-PG-induced periodontitis was confirmed by immunohistochemistry using anti-11β-HSD1 antibody. These results further suggest a role for 11β-HSD1 in the pathogenesis of chronic periodontitis.