Wu, Z.Z., Nash, J. and Morrison, H. (1992) Organic Photochemistry. 97. Antenna-Initiated Photochemistry in Polyfunctional Steroids. Photoepimerization of 3.alpha.- (Dimethylphenylsiloxy)-5.alpha.-Androstane-6,17-Dione and Its 3.beta. Isomer by Through-Bond Exchange Energy Transfer. Journal of the American Chemical Society, 114, 6640-6648.
https://doi.org/10.1021/ja00043a005

has been cited by the following article:

• TITLE: Isolation and Characterization of Photodegradation Impurity in Budesonide Drug Product Using LC-MS and NMR Spectroscopy

  AUTHORS: Arun Bhutnar, Sachin Khapare, Anita Desai, Smitha Dsouza

  KEYWORDS: Budesonide, Lumibudesonide, Photodegradation, LC-MS/MS, NMR, Degradation Study

  JOURNAL NAME: American Journal of Analytical Chemistry, Vol.8 No.7, July 6, 2017

  ABSTRACT: Budesonide is a corticosteroid used for the treatment of asthma via various matrices and inhalation mechanisms. An unknown peak of Budesonide aqueous formulation has been investigated during stability study wherein the impurity level observed around 0.1% well below the threshold 0.5%. The approach to identify anonymous species was adopted as first to generate the impurity in sample, isolate, enrich and was subjected to LC-MS/MS and NMR for spectral studies. Based on the spectral data the anonymous species were identified as a “Lumibudesonide’’ ((5aR,5bS,5cS,6S,7aS,7bS,10aR,11aS,11bS)-6-hydroxy-7b-(2-hydroxyacetyl)-5b,7a-dimethyl-9-propyl 1,5a,5b,5c,6,7,7a,7b,10a,11,11a,11b dodecahydrocyclopenta[2'',3'']cyclopropa [1'',2'':3', 4']benzo [1',2':4,5]indeno [1,2-d][1,3]dioxol-5(2H)-one), which is observed in photolysis of Budesonide.