Rongione, J.C., Galante, J.H., Clauss, S.L., Bernhardt, R.J. and Xayariboun, P. (2004) Manufacture of Conjugated Linoleic Salts and Acids. U.S. Patent and Trademark Office, Washington DC, US Patent No. 20040225141.

has been cited by the following article:

• TITLE: Response Surface Optimization of a Solvent Free Production of cis-9, trans-11 and trans-10, cis-12 Isomers of Conjugated Linoleic Acid Using High Linoleic Sunflower Oil

  AUTHORS: Sara Koohikamali

  KEYWORDS: CLA Methyl Esters, Isomerization, Commercial CLA, RSM, Phase Transfer Catalyst, PEG400

  JOURNAL NAME: Food and Nutrition Sciences, Vol.8 No.6, June 28, 2017

  ABSTRACT: The most dominant and beneficial conjugated linoleic acids isomers (CLAs) with miscellaneous biological tasks are 9c11t-C18:2 and 10t12c-C18:2. The problem with most of the commercial CLA produced by non-optimized conventional approaches is the heterogeneity of their isomers and undesirable toxic by-products. In this study, optimization of the isomerization of the fatty acid methyl esters of the high linoleic sunflower oil was investigated through response surface methodology (RSM). The reaction temperature, the concentration of PEG400 and NaOCH3 had positive influence on the total conjugated linoleic acid methyl esters (CLAME) production as response. However, the effect of the polyethylene glycol 400 (PEG400) concentration was more significant on response than those of other factors (p i.e., based on the mass percentage of total fatty acid methyl esters mixture) was at 5% w/w NaOCH3, 1.06% w/w PEG400 and temperature of 140°C.