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has been cited by the following article:

• TITLE: Stimulation of Phagocytosis and Production of Antibodies against Canine Herpesvirus Type 1 by Pidotimod (AdimodTM)

  AUTHORS: Edgar G. Valdivia Lara, Andrés Ángeles Aldana, Jesica I. Ángeles Solis, Patricia Miranda Castro, Juan C. Del Río García, Guillermo Valdivia Anda

  KEYWORDS: Phagocytosis, Canine Herpesvirus, Pidotimod Stimulation

  JOURNAL NAME: Open Journal of Veterinary Medicine, Vol.7 No.4, April 29, 2017

  ABSTRACT: Neutrophils are the most important circulating phagocytes. Circulating mono-cytes and precursors of tissue macrophages also have the ability to phagocytize. Pidotimod (ADIMODTM) exerts immunostimulatory and immunoregulatory effects through the stimulation and regulation of cellular immune responses by lymphocytes Canine herpesvirus (CHV) mainly affect puppies between the first and second weeks of age, causing high morbidity in the litter. To date, there is only one commercial vaccine in Europe to prevent disease. In this work, inactivated CHV cultures were inoculated in rabbits, adsorbed and not adsorbed to chitosan nanoparticles. Phagocytosis in the presence or absence of specific antibodies was measured. Response of virus neutralizing antibodies was also evaluated. AdimodTM enhanced the nonspecific and specific phagocytotic response. The association of the virus to the nanoparticles increased the phagocytic ability of blood cells; however, AdimodTM alone had a greater effect on phagocytic activity and generated a stronger immune response that corresponded to the increased phagocytosis (p TM was used.