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has been cited by the following article:

• TITLE: The Uses of 2-Amino-4-Phenylthiazole in the Synthesis of Coumarin, Pyran, Pyridine and Thiazole Derivatives with Antitumor Activities

  AUTHORS: Faten I. Hamed, Abeer A. Mohamed, Amr S. Abouzied

  KEYWORDS: Thiazole, Pyran, Pyridine, Antitumor

  JOURNAL NAME: Open Access Library Journal, Vol.4 No.5, May 4, 2017

  ABSTRACT: The thiazole derivative 3 was used for a series of heterocyclization reaction to produce pyran, pyridine and thiazole derivatives. The cytotoxicity of the newly synthesized compounds was studied against the six cancer cell lines namely NUGC, HR, DLD1, HA22T, HEPG2, MCF, HONE1 and normal fibroblast cells (WI38). The results showed that most of the synthesized compounds were of high potency. Among the tested compounds, 2-Amino-4-(4-chlorophenyl)-6-(4-phenylthiazol-2-yl)-4H-pyran-3,5-dicarbonitrile 17b showed the highest potency among the tested compounds.