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F. W. Bell, A. S. Cantrell, M. Hogberg, S. R. Jaskunas, N. G. Johansson, C. L. Jordon, M. D. Kinnick, P. Lind, J. M. Morin Jr, R. Noreen, B. Oberg, J. A. Palkowitz, C. A. Parrish, P. Pranc, C. Sahlberg, R. J. Ternansky, R. T. Va-sileff, L. Vrang, S. J. West, H. Zhang and X. X. Zhou, “Phenethylthiazolethiourea (PETT) Compounds, a New Class of HIV-1 Reverse Transcriptase Inhibitors. 1. Syn-thesis and Basic Structure-Activity Relationship Studies of PETT Analogs,” Journal of Medicinal Chemistry, Vol. 38, No.
has been cited by the following article:
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TITLE:
Preparation of α-Bromoketones and Thiazoles from Ketones with NBS and Thioamides in Ionic Liquids
AUTHORS:
Yuhta Izumisawa, Hideo Togo
KEYWORDS:
Ketone, α-Bromoketone, Thiazole, NBS, Thioamide, Ionic Liquid
JOURNAL NAME:
Green and Sustainable Chemistry,
Vol.1 No.3,
August
31,
2011
ABSTRACT: Ketones smoothly reacted with NBS in the presence of a catalytic amount of ptoluenesulfonic acid to give α-bromoketones in good yields in typical ionic liquids, such as [bmim]PF6 and [bmpy]Tf2N, and the ionic liquids could be repeatedly used for the same reaction after the extraction of the α-bromoketones. Then, the one-pot conversion of ketones into thiazoles by the treatment with NBS, and subsequently with thioamides could be also carried out in [bmim]PF6 and [bmpy]Tf2N, respectively Thus, [bmim]PF6 and [bmpy]Tf2N could be used as recyclable reaction media for the preparation α-bromoketones and thiazoles from ketones.