TITLE:
Relationship of Density of Specific Prostate Antigen (DPSA) with Prostate Histopathology: A Comparative Study of Patients Addressed in a School Hospital
AUTHORS:
Marcos Benedito Figueiredo Brandão, Maria Benedita Figueiredo Brandão, Elias Sobreira Sathler, Richard Raphael Borges Tavares Vieira, Carolina Cadinelli Vieira, Pedro Kozlowsky de Alencar, Marcus Vinicius de Mello Pinto, Lamara Laguardia Valente Rocha, Lina Claudia Pereira Lopes, Daniel Almeida da Costa, Carlos Henrique Diniz Branco
KEYWORDS:
Prostate Cancer, Adenocarcinoma, Benign Prostatic Hyperplasia, Prostate Biopsy
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.5 No.3,
March
23,
2017
ABSTRACT: Background: The prostate is the site of problems that have great clinical relevance. Beside this, the alterations in their volume can be divided into benign or malignant pathologies, but of multifactorial cause and there is no examination that alone is reliable for the diagnosis. Despite the evolution of the various methods of diagnostic imaging in the evaluation of pelvic diseases, the diagnosis of prostate cancer still requires histological confirmation obtained by transrectal ultrasound guided biopsy, a procedure that is generally safe and well tolerated by the patients. The most common histological type found in prostate biopsies is adenocarcinoma. Methodology: The objective of this study was to study the values of density of the prostate-specific antigen (DPSA) compared to histopathological results of prostate biopsy, patients attended at the Urology Outpatient Clinic of the Luiz Gioseffi Jannuzzi School Hospital from 1999 to 2007, using Exploratory, retrospective and documentary descriptive study. The sample was divided into groups of patients with adenocarcinoma and patients without adenocarcinoma, who presented only benign prostatic hyperplasia. Results: Of the 251 patients undergoing prostate biopsy, 124 were diagnosed with adenocarcinoma and 127 without adenocarcinoma. It was observed in this study that the DPSA was higher in adenocarcinoma than in the cases of patients with prostatic hyperplasia alone, and could therefore be used as an auxiliary tool in both diagnosis and follow-up of patients with adenocarcinoma. Conclusion: In this study, it can be observed that DPSA was higher in patients presenting with adenocarcinoma than in patients presenting only Benign Prostatic Hyperplasia (BPH), reinforcing its promising role to assist in the diagnosis and follow-up of patients with adenocarcinoma.