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has been cited by the following article:

• TITLE: Carobomer Based Controlled Release Designs of Atorvastatin Calcium Tablets Evaluated Using Quality by Design (QbD) Approach

  AUTHORS: Arunkanth Krishnakumar Nair, Peddakotla Venkata Ramana, P. Venkat Bhaskar Rao, Bapatu Hanimi Reddy, Hari Kishan Reddy Ganthi, Useni Reddy Mallu

  KEYWORDS: Atorvastatin Calcium Tablets, Controlled Release, Carbomer, Release Controlling Polymer, Gelling Agent, Povidone

  JOURNAL NAME: American Journal of Analytical Chemistry, Vol.8 No.3, March 13, 2017

  ABSTRACT: The study carried out here was focused on developing conventional monolithic controlled release matrix tablet of Atorvastatin calcium using carbomer as release controlling polymer. This system ensures the drug release at the alkaline pH region where the drug has got maximum solubility. Further the study was concentrated on comparing the impact of gelling agent polyvinyl pyrrolidone on drug release. Quality by design tools were considered during formulation development and the polymer concentrations were optimized adopting the statistical tool, design of experiments (DoE). The optimized formulation of present study exhibited desired controlled drug release characteristics in the alkaline pH conditions and at acidic environment the drug dissolution was minimal as intended.