Article citationsMore>>
Barth, R.F., Yang, W., Rotaru, J.H., Moeschberger, M.L., Boesel, C.P., Soloway, A.H., Joel, D.D., Nawrocky, M.M., Ono, K., Goodman, J.H. (2000) Boron neutron cupture therapy of brain tumors: enchanced survival and cure following blood-brain barrier disruption and ?ntracarotid injection of sodium borocaptate and boronophenyl aniline. Int J Radiat Oncol Biol Phys, 47(1), 209.
has been cited by the following article:
-
TITLE:
Bioengineering functional copolymers. XII. Interaction of boron-containing and PEO branched derivatives of poly(MA-alt-MVE) with HeLa cells
AUTHORS:
Mustafa Türk, Zakir M. O. Rzayev, Gülcihan Kurucu
KEYWORDS:
Synthesis; Organoboron Copolymers; Structure-Property Relations; Cytotoxicity; Antitumor Activity; Apoptotic Effect
JOURNAL NAME:
Health,
Vol.2 No.1,
January
15,
2010
ABSTRACT: Novel boron-containing bioengineering copoly- mer and its α-hydoxy-ω-methoxy-poly(ethy- lene oxide (PEO) macrobranched derivatives were synthesized by (1) partially amidolysis of poly(maleic anhydride-alt-methyl vinyl ether) w?th ethanolamine ester of diphenylboronic acid and (2) esterification of synthesized B-con- taining copolymers with PEO. They had a com- bination of hydrophilic/hydrophobic linkages, free carboxylic groups, positive charges and an ionized organoboron linkage as antitumor sites, along with an ability to interact with HeLa cells. The structure, composition and properties (cy- totoxicity and antitumor activity) of synthe- sized copolymers were investigated. In vitro cytotoxicity results, obtained by the fluore scence microscopy measurements indicate that unlike the virgin copolymer, boron-containing and PEO macrobranched derivatives exhibit higher antitumor activity. It was found that organoboron copolymer exhibits the most apo- ptotic and necrotic effects against HeLa cells whereas a minor effect relative to cancer cells was observed on L929 Fibroblast cells.
Related Articles:
-
Dongmei Yang, Robert A. Knight, Yuxia Han, Kishor Karki, Jianfeng Zhang, Michael Chopp, Donald M. Seyfried
-
Robyn Gebhard, Courtney Huff, Mathew Osborne, Lisa Riegle, Marie Kelly-Worden
-
Heather A. Bullen, Ruth Hemmer, Anthony Haskamp, Chevelle Cason, Stephen Wall, Robert Spaulding, Brett Rossow, Michael Hester, Megan Caroway, Kristi L. Haik
-
Selva Rivas-Arancibia, Luis Fernando Hernández-Zimbrón, Erika Rodríguez-Martínez, Gabino Borgonio-Pérez, Varsha Velumani, Josefina Durán-Bedolla
-
Yannis Karamanos