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Shen, F., Chen, J., Guo, S., Zhou, Y., Zheng, Y., Yang, Y., Zhang, J., Wang, X., Wang, C., Zhao, D., Wang, M., Zhu, M., Fan, L., Xiang, J., Xia, Y., Wei, Q., Jin, L., Wang, J. and Wang, M. (2016) Genetic Variants in miR-196a2 and miR-499 Are Associated with Susceptibility to Esophageal Squamous Cell Carcinoma in Chinese Han Population. Tumor Biology, 37, 4777-4784.
https://doi.org/10.1007/s13277-015-4268-3
has been cited by the following article:
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TITLE:
The Association between miR-196a2 rs11614913 Polymorphism and Digestive System Cancer Risk: A Meta-Analysis of 34 Studies
AUTHORS:
Rongce Zhao, Jing Zhou, Fei Liu, Yonggang Wei, Kefei Chen, Bo Li
KEYWORDS:
miR-196a2, rs11614913, Polymorphism, Digestive System Cancers, Meta-Analysis
JOURNAL NAME:
Open Journal of Internal Medicine,
Vol.6 No.4,
November
30,
2016
ABSTRACT: Background: MicroRNAs (miRNAs) negatively regulate the gene expression and act as tumor suppressors or oncogenes in carcinogenesis. The association between single nucleotide polymorphism (SNP) in miR-196a2 rs11614913 and the susceptibility of digestive system cancers was inconsistent in previous studies. Methods: A standardized search of PubMed, Embase, and Cochrane library databases for publications on miR-196a2 rs11614913 polymorphism and digestive system cancer risk was performed. Then the genotype data were analyzed in a meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association. Test of heterogeneity, sensitivity analysis and assessment of publication bias were conducted in the present meta-analysis by STATA software 12.0. Results: An updated meta-analysis based on 34 independent case-control studies consisting of 13,013 cases and 16,046 controls was performed to address this association. There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations. Moreover, subgroup analysis revealed that variant C allele increased risk of colorectal carcinoma, gastric cancer and hepatocellular carcinoma (HCC), compared with wild T allele. Conclusions: There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations.
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