TITLE:
The Association between the KLF14 rs4731702 SNP and the Lipid Profile in Type 2 Diabetes Mellitus Patients: A Study in San Luis City, San Luis, Argentina
AUTHORS:
Micaela Fernanda Álvarez, Miriam Ester Vásquez Gómez, Irma Inés González, Gustavo Fernández, Susana Siewert
KEYWORDS:
KLF14, Single Nucleotide Polymorphism, Type 2 Diabetes Mellitus, Lipid Profile, Dyslipidemia
JOURNAL NAME:
Open Access Library Journal,
Vol.3 No.11,
November
25,
2016
ABSTRACT: The single nucleotide polymorphism (SNP) rs4731702 in the KLF14 transcription factor gene has been associated with type 2 diabetes mellitus (T2DM) and HDL-c concentrations. The aim of the present study was to determine the distribution of KLF14 rs4731702 SNP and evaluate the association between this SNP and serum lipid profile in T2DM patients in a patient population at San Luis province, Argentina. A total of 73 volunteers (26 T2DM patients and 47 healthy age-matched controls) were genotyped for KLF14 rs4731702 SNP by Tetra Primer ARMS-PCR. The KLF14 genotypes distribution among study groups was not significantly different. In T2DM patients, there was a difference in HDL-c values and TC/HDL-c ratio, with T carriers of the rs4731702 SNP (non C/C) having higher HLD-c and lower TC/HDL-c ratio values than C/C homozygotes (p = 0.0047 and 0.0041, respectively). HDL-c levels were higher in diabetic patients, without dyslipidemia, carrying the genotype non- C/C (p = 0.023). Conversely, TC and LDL-c levels were lower in diabetic patients, without dyslipidemia, in non-C/C carriers (p KLF14 activity in diabetic patients as a consequence of C/C genotype and insulin resistance.