TITLE:
Confrontation between Myelogram and Cytogenetics in 35 CML Malagasy Patients
AUTHORS:
Harioly Nirina Marie Osé Michael, Hoahy Rasoanandrasana, Raheritiana Todisoa Mahenina, Rasolonjatovo Anjaramalala Sitraka, Rakoto Alson Aimée Olivat, Rasamindrakotroka Andry
KEYWORDS:
Chronic Myeloid Leukemia, Madagascar, t (9; 22), BCR-ABL
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.7 No.12,
November
16,
2016
ABSTRACT: Introduction: Chronic Myeloid Leukemia is a myeloproliferative
disorder affecting hematopoietic stem cells. The specific cytogenetic
abnormality is translocation (9; 22) which leads to the BCR-ABL fusion gene.
Methods: We
did a bone marrow aspiration in our
laboratory of haematology of university hospital Joseph Ravoahangy Andrianavalona
Antananarivo. We studied myelogram and compared its result to the cytogenetic result. Results: Men were the most affected by this pathology and
diagnostic average age was
51.2 years. Splenomegaly leukocytosis and myelemia were often present.
Myelogram showed granulocytic hyperplasia and the t (9; 22) were present in all the patients. Conclusion: Diagnosis is based on data from the NFS, the
myelogram, the search for the Philadelphia chromosome and BCR-ABL fusion gene.
These specialized techniques are still inaccessible for Malagasy patients.