TITLE:
Semi-Automated Synthesis of [F-18]FBAM, a Thiol Reactive Prosthetic Group, Using Continuous Flow Chemistry
AUTHORS:
Murthy R. Akula, Srinivasa R. Marepally, Lee T. Collier, W. George Kabalka
KEYWORDS:
Bifunctional Agent, Micro-Reactor, 6-Bromohexnol, Radiofluorination, Appel Reaction
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.6 No.3,
September
26,
2016
ABSTRACT: [F-18]FBAM, a thiol reactive bifunctional agent, was successfully synthesized using continuous flow chemistry in a micro reactor that is part of Advion NanoTek Micro-fluidic Synthesizer. As the radiofluorination was carried out microfluidically, a very small amount of precursor was used and over all radiochemical yield was 38% ± 4% (n = 8, decay corrected) and the radiochemical purity was ≥98% with specific activity of 430 mC/μmol. The total reaction time including HPLC purification was 55 min that is 14 min more than manual synthesis and 6 min less than fully automated synthesis.