TITLE:
Genoautotomy (Genome 'Self-Injury') in Eukaryotic Cells: A Cellular Defence Response to Genotoxic Stress
AUTHORS:
Gao-De Li
KEYWORDS:
Genoautotomy, Programmed Genome “Self-Injury”, Genotoxic Stress, Single-Stranded DNA (ssDNA), Apoptosis, Autophagy, Anticancer Agent, Chloroquine
JOURNAL NAME:
Open Access Library Journal,
Vol.3 No.8,
August
17,
2016
ABSTRACT:
This paper proposes that eukaryotic cells, under severe genotoxic stress,
can commit genoautotomy (genome “self-injury”) that involves cutting and
releasing single-stranded DNA (ssDNA) fragments from double-stranded DNA and
leaving ssDNA gaps in the genome. The ssDNA gaps could be easily and precisely
repaired later. The released ssDNA fragments may play some role in the
regulation of cell cycle progression. Taken together, genoautotomy causes
limited nonlethal DNA damage, but prevents the whole genome from lethal damage,
and thus should be deemed as a eukaryotic cellular defence response to
genotoxic stress.