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has been cited by the following article:

• TITLE: Novel Identification of LYVE-1 Positive Macrophages in Rheumatoid Synovial Tissue

  AUTHORS: Lisa J. M. Rump, Derek L. Mattey, Oksana Kehoe, Jim Middleton

  KEYWORDS: LYVE-1, Macrophage, Rheumatoid Arthritis, Endothelial, Lymphatic

  JOURNAL NAME: Open Journal of Rheumatology and Autoimmune Diseases, Vol.6 No.3, August 17, 2016

  ABSTRACT: Objective: LYVE-1+ macrophages are observed in a range of cancers, where they play a role in tumour lymphangiogenesis. In rheumatoid arthritis (RA), lymphangiogenesis increases in the early stage of the disease and decreases as it progresses, potentially exacerbating inflammatory cell persistence. We investigated whether LYVE-1+ macrophages were present in RA synovium. Methods: Synovial tissue from RA patients was obtained at joint replacement surgery and immunohistochemistry was performed to visualise LYVE-1+ and CD68+ cells. Results: LYVE-1+ macrophages were present in rheumatoid synovial tissue, the first observation of this kind. Conclusion: Despite the reduction in lymphangiogenesis in chronic RA, LYVE-1 positive macrophages are present and there is a potential role for macrophages in the generation of lymphatic vessels.