Article citationsMore>>
Dai, R.L., Guo, Y., Frey, R.R., Ji, Z., Curtin, M.L., Ahmed, A.A., Albert, D.H., Arnold, L., Arries, S.S., Barlozzari, T., Bauch, J.L., Bouska, J.J., Bousquet, P.F., Cunha, G.A., Glaser, K.B., Guo, J., Li, J., Marcotte, P.A., Marsh, K.C., Moskey, M.D., Pease, L.J., Stewart, K.D., Stoll, V.S., Tapang, P., Wishart, N., Davidsen, S.K. and Michaelides, M.R. (2005) Thienopyrimidine Ureas as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors. Journal of Medicinal Chemistry, 48, 6066-6083.
http://dx.doi.org/10.1021/jm050458h
has been cited by the following article:
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TITLE:
Synthesis and Antitumor Activity of Novel Thienopyrimidine Derivatives Containing Thiosemicarbazide Moiety
AUTHORS:
Samir B. Salib, Omneya M. Khalil, Mona M. Kamel, Yara El-Dash
KEYWORDS:
Synthesis, Thieno[2, 3-d]Pyrimidine, Thiosemicarbazides, Anticancer Agents
JOURNAL NAME:
Open Access Library Journal,
Vol.3 No.7,
July
26,
2016
ABSTRACT:
The present study focused on synthesizing a series of novel derivatives
of 4-aryl-1-[2-(3-benzyl-4-oxo(3H)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-ylsulphanyl)
acetyl] thiosemicarbazide 5a-d and evaluating their antitumor activity. The
structure of the synthesized compounds has been elucidated on the basis of
elemental analyses and spectroscopic methods (IR, 1H-NMR, 13C-NMR
and MS). The in vitro cytotoxic activity of the synthesized derivatives
was evaluated against two human cell lines: prostate cancer (PC-3) and colon
cancer (HCT-116).
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