TITLE:
Andrographis peniculata: Capabilities against Free Radicals, Lipid Peroxidation, Hepatotoxicity, and Nephrotoxicity
AUTHORS:
Godwin O. Adejo, Joseph M. Gnimintakpa, Olufunsho D. Olowoniyi, Paulinus Obinna Matthew
KEYWORDS:
Andrographis peniculata, Peroxidation, Hepatotoxicity, Nephrotoxicity
JOURNAL NAME:
Open Access Library Journal,
Vol.3 No.7,
July
19,
2016
ABSTRACT:
This work was about Andrographis peniculata (Burm. F). Ab initio, the LD50 test showed
non-toxicity at the highest administered dose of 5000 mg/kg in rats. Male
albino Wistar rats were treated with daily single doses of ethanol extracts
(100/200/500 mg/kg) of Andrographis peniculata (A.p.) for 14 days with intermittent administration, i.p.,
of CCl4 every four days. Liver and kidney TBARS concentrations showed lower values with increased
doses of extract administration. In both cases, “CCl4 A.p. 500 mg/kg” values compared to “CCl4 Silymarin” group, while “CCl4 A.p. 100 mg/kg” showed no significant difference
from “CCl4 only” group. The “NC” (normal control) however, presented
the least concentration of 66.17 ± 2.74 and 38.04 ± 4.34 nmol/mg protein, respectively. Total and Indirect bilirubin concentrations indicated decreased values with increasing doses, such
that respectively, the lowest values of 1.18 ± 0.47 and 0.98 ± 0.31 mg/dl in the “CCl4 A.p. 500 mg/kg” group were observed.
There was no significant difference among all the various groups except the
“NC” which showed the least value. Urea and creatinine levels were
significantly higher (p ≤ 0.05) in the “CCl4 only” group than
all others. Liver function parameters, viz., AST and ALT indicated significantly
higher values in the “CCl4 only” group, compared to all others (p ≤ 0.05). Values obtained for “CCl4 A.p. (500 mg/kg)” were comparable to the
“NC” and “CCl4 Silymarin” groups.