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has been cited by the following article:

• TITLE: New Sulfonamides Derived from Carvacrol: Compounds with High Antibacterial Activity against Resistant Staphylococcus aureus Strains

  AUTHORS: Aldo Sena de Oliveira, Luana Canzian Llanes, Inês Maria Costa Brighente, Ricardo José Nunes, Rosendo Augusto Yunes, Nilton Máximo Junior, Ana Milda Karsten Baumgart, Anays Noumeh Aust, Alexandre Bella Cruz

  KEYWORDS: Sulfonamides, Carvacrol, Antibacterial, Staphylococcus aureus, Synergism

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.4 No.7, July 20, 2016

  ABSTRACT: Nine new sulfonamides derived from carvacrol were prepared through a reaction between 4-hydroxy-2-isopropyl-5-methyl benzene sulfonyl chloride with various amines in excellent yields (76% - 92%). The sulfonamides were characterized using spectrometric and spectroscopic methods. Among these compounds, three derivatives showed excellent results in antibacterial activity against resistant S. aureus strains, with MIC values ranging from 3.9 to 62.50 ppm. The sulfonamide derivative of 4-methylaniline (SULF-1) had the best performance for all tested strains of bacteria (MIC = 3.9 to 15.62 ppm). Furthermore, the sulfonamide derivative of 4-fluoro aniline (SULF-3), which also presented promising results, was found to have a synergistic effect when combined with tetracycline and partial synergistic effect when combined with ampicillin, exhibiting an FIC index between 0.50 and 0.75. The sulfonamide derivative of 4-methylaniline had a synergistic effect in combination with erythromycin exhibiting an FIC index of 0.37. Carvacrol in association with the antibiotics tested did not have a synergistic effect.