TITLE:
Benign Breast Tumors among Senegalese Women: Diversity and Genetic Evolution of D-Loop
AUTHORS:
Daniel Doupa, Marc Noël Badji, Fatimata Mbaye, Sidy Ka, Ahmadou Dem, Mamadou Kane, Mbacké Sembène
KEYWORDS:
Tumor, Benign, Breast Cancer, D-Loop, Diversity, Genetic Evolution, Senegal
JOURNAL NAME:
Open Access Library Journal,
Vol.2 No.8,
August
20,
2015
ABSTRACT:
Subsaharan Africa, as in Senegal, breast cancer is the second after that
of cervical in women. However, although most of the studies on breast
pathology for cancer, the overwhelming majority of breast lesions, palpable or
not are benign and some of them can become cancerous. So this research is
done to understand the impact of diversity and genetic evolution of the D-loop
in benign breast lesions in senegalese women. The variability of the D-loop was
investigated by PCR-sequencing, in twenty eight patients with benign breast
tumor. The results revealed a significant presence of specific variants for
breast benign tissue, as well as control tissues. The C150T mutation was
associated with protection to the presence of benign breast tumors and G247A
mutation implicated in an increased risk. Patients of mitochondrial haplogroup
L would be significantly more susceptible to these benign breast lesions. And
the study of the genetic evolution of breast benign tumors revealed that the
D-Loop is not under selection. Finally, a significant correlation was
associated with haplotypes C309CC and witnessed the D310, which respectively
constitute increased risk groups and susceptible to the contraction of benign
breast lesions. All these results allowed to have a global view on the
influence of pathogenic mutations on diversity and genetic evolution of the
D-Loop observed in senegalese patients with benign breast tumor.