TITLE:
Incidence and Predictors of Tuberculosis among HIV/AIDS Infected Patients: A Five-Year Retrospective Follow-Up Study
AUTHORS:
Mulugeta Dalbo, Alemu Tamiso
KEYWORDS:
Tuberculosis, HIV Infection, Incidence, Predictors, Arba Minch General Hospital, Ethiopia
JOURNAL NAME:
Advances in Infectious Diseases,
Vol.6 No.2,
June
22,
2016
ABSTRACT: Background: Despite
increased deliverance of antiretroviral therapy (ART), morbidity and mortality
from TB are still predominant among HIV/AIDS infected patients in Ethiopia.
Thus, current study aimed to determine magnitude and predictors of tuberculosis
among cohort of HIV infected patients
at Arba Minch General Hospital, Ethiopia, 2015. Methods: Hospital based
retrospective follow-up study was
conducted among study population which was HIV/AIDS infected individuals
registered from September 2007 to 2013. The data were collected using
structured data abstraction form and four ART trained nurses were used to
abstract the data. The data were checked for completeness,
cleaned and entered into Epi Info 7.0 and analyzed using SPSS version (IBM-21).
Results were summarized by using table of frequency, graph, and measure of
central tendency. Statistical significance was inferred at P-value ≤ 0.05.
Adjusted odd ratio (AOR) with 95% confidence interval (CI) was used to
determine predictors. Result: Four hundred ninety six patient’s charts were abstracted. Cumulative and
incidence density of tuberculosis were 21.4% (95% CI: 21.3, 21.44) and 5.36 per 100 person
year respectively. Cigarette smokers (AOR: 2.82, 95% CI (1.27 - 6.27)), household with family
size of 3 - 4 (AOR: 2.26, 95% CI (1.14 - 4.50)), baseline WHO clinical stage
III (AOR: 20.26, 95% CI (7.09 - 57.6)) and IV (AOR: 22.9, 95% CI (6.91 - 76.4))
and heamoglobin level of high incident
tuberculosis cases were established among HIV infected patients and history of
cigarette smoking; family size; hemoglobin level and base line WHO clinical
stage were responsible for this
incidence. Therefore; early initiation of HAARTas per current guideline should
get stressed, and the finding that smoking was important predictors for TB in
Ethiopia had obvious TB control implication
which required high attention focused on fighting against cigarette smoking among HIV infected cohort.