TITLE:
A Short Glance at the Neural Circuitry Mechanism Underlying Depression
AUTHORS:
Chanyi Lu, Qiqin Li, Yaoyao Li, Yun Wang, Yun-Feng Zhang
KEYWORDS:
Pathophysiology, Depression-Like Behavior, Neural Circuitry
JOURNAL NAME:
World Journal of Neuroscience,
Vol.6 No.3,
June
16,
2016
ABSTRACT: Depression leads to a
large social burden because of its substantial impairment and disability in
everyday activities. The prevalence and considerable impact of this disorder
call for a better understanding of its pathophysiology to improve the
diagnosis, treatment and prevention. Though productive animal models and
pathophysiological theories have been documented, it is still very far to
uncover the complex array of symptoms caused by depression. Moreover, the
neural circuitry mechanism underlying behavioral changes in some
depression-like behavior animals is still limited. Changes in the neural
circuitry of amygdala, dorsal raphe nucleus, ventral tegmental area,
hippocampus, locus coeruleus and nucleus accumbens are related to depression.
However, the interactions between individual neural circuitry of different
brain areas, have not yet been fully elucidated. The purpose of the present
review is to examine and summarize the current evidence for the
pathophysiological mechanism of depression, with a focus on the neural
circuitry, and emphasize the necessity and importance of integrating individual
neural circuitry in different brain regions to understand depression.