Kris-Etherton, P., Hu, F.B., Ros, E. and Sabaté, J. (2008) The Role of Tree Nuts and Peanuts in the Prevention of Coronary Heart Disease: Multiple Potential Mechanisms. The Journal of Nutrition, 138, 1746S-1751S.
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TITLE:
Feeding Walnuts and Peanuts Reduced Development of Azoxymethane-Induced Precancerous Lesions
AUTHORS:
Hadyn Mathew Reid, Rajitha Sunkara, Louis Shackelford, Lloyd T. Walker, Martha Verghese
KEYWORDS:
Aberrant Crypt Foci (ACF), Azoxymethane (AOM), Chemoprevention, Fisher 344 Rats, Nuts
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.7 No.6,
May
25,
2016
ABSTRACT:
Walnuts and peanuts contain phytochemicals that exhibit properties that
may prevent colon cancer development. The objective was to determine the
potential of walnuts and peanuts on Azoxymethane (AOM) induced Aberrant Crypt
Foci (ACF) and the activity of detoxification enzymes: Glutathione S-Transferase
(GST), Catalase (CAT), and Superoxide Dismutase (SOD) in Fisher 344 male rats. After
1 week acclimatization period, 20 rats were randomly divided into 5 groups. One
was fed AIN93G Control (C) diet, 4 groups were fed walnuts (W) and peanuts (P)
at 5% and 10%. At 7 - 8 weeks, rats received AOM injections at 16 mg/kg body
weight (subcutaneously). Rats were killed by CO2 asphyxiation at 17
weeks. Enzyme activities GST, CAT and SOD were determined. ACF incidence in
rats fed W (5% and 10%) was 131 and 95, and in those fed P (5% and 10%) was 110
and 56. Rats fed W and P had a significant (p p
Related Articles:
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Karaskov Alexander, Kamenskaya Oksana, Levicheva Elena, Loginova Irina, Okuneva Galina, Cherniavsky Aleksander, Kliver Evgeni, Volkov Alexander
DOI:
10.4236/health.2011.35047
4,856 Downloads 9,014 Views Citations
Pub. Date:
May
19,
2011
