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has been cited by the following article:

• TITLE: Phylogenetic Analysis of Frequent Recombinant Region in Micropeptin Biosynthetic Gene Cluster among the Genus Microcystis

  AUTHORS: Tomoyasu Nishizawa, Takamasa Miura, Ayana Futamura, Makoto Shirai

  KEYWORDS: Cyanobacteria, Microcystis, Micropeptin Biosynthetic Gene, Phylogenetic Analysis

  JOURNAL NAME: Advances in Microbiology, Vol.6 No.5, April 27, 2016

  ABSTRACT: The gene cluster for the biosynthetic of a nonribosomal peptide, cyanopeptolins and micropeptin (MCN), was identified in Microcystis strains and halogenated MCN-producing Microcystis were found to possess the halogenase gene, mcnD, between nonribosomal peptide synthetase genes, mcnC and mcnE. A comparative sequence analysis of the mcn gene cluster between halogenated and non-halogenated MCN-producing strains revealed mosaic sequence traces from mcnD in the non-coding region between mcnC and mcnE in the latter strains. A phylogenetic analysis based on a 170-bp non-coding region including the mcnD traces suggests that the recombination events occurred in a particular region of the Microcystis’ mcn gene. This study provides novel insight into the ecological patterning of widespread Microcystis species.