TITLE:
The Effect of Fullerenol Combined with Cisplatin on the Proliferation of Cervical Cancer HeLa Cells
AUTHORS:
Yuan Niu, Chao Yan
KEYWORDS:
Fullerenol, Cisplatin, HeLa Cells, Proliferation, Apoptosis
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.7 No.3,
March
31,
2016
ABSTRACT: This study aimed to investigate the effect of fullerenol combined with cisplatin
on the proliferation of cervical cancer HeLa cells in order to provide new ideas
and laboratory theoretical basis for the clinical treatment of cervical cancer.
Cervical cancer cell line HeLa cells in vitro were treated with different concentrations of fullerenol, different concentrations
of cisplatin, and different concentrations of fullerenol combined with cisplatin,
after 24 h, 48 h, 72 h, microscope changes in cell morphology; MTT assay was used
to determine the effect of drugs on the proliferation of HeLa cells. Fullerenol
and cisplatin alone can inhibit the proliferation of HeLa cells in a dose-dependent
and time-dependent manner; compared with cisplatin alone, different concentrations
of fullerenol combined with cisplatin significantly increased the apoptosis rate
of HeLa cells (P in vitro is more significant,
resulting in a stronger anti-cancer effect.