TITLE:
The Results Observation on Adjuvant Chemotherapy with Microwave Hyperthermia and Stereotactic Radiotherapy in Retreated Elderly Patients with Advanced (III/IV Stage) Lung Cancer
AUTHORS:
Xihao Yu, Xinping Li, Guiyun Dong, Wenyan Yu, Jianping Wang, Ying Xiong
KEYWORDS:
Elderly Patients, Chemotherapy, Combined Radiotherapy, Lung Cancer
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.4 No.3,
March
30,
2016
ABSTRACT:
Objective: To evaluate the significance
of adjuvant chemotherapy and radiotherapy (Gamma-knife) in the elderly patients
with retreated advance lung cancer. Methods 83 patients (age 50 to 81 years)
with retreating advanced (III/IV stage) lung cancer were divided into three
groups according to patients received treating by different methods. The cases
were treated by synchronous chemo-radiotherapy (A group), sequentially chemo-radiotherapy
(B group) and continuous systematized chemotherapy alone (C group). The
systemic 3-dimensional orientation apparatus was used in radiotherapy. The
chemotherapy regimen in combined radiotherapy was given by common first line regimen
on lung cancer. The regimen of chemotherapy combated with whole body
hyperthermia by using micro-wave on abodeman about 2 or 3 line was used in C
group only. Results: The overall responses rates (RR) of A, B and C groups were
17.1%, 11.5% and 31.8%, but it was non-significance difference (P > 0.05).
Overall responses rates (RR) of III and IV stage groups were 18.2% and 20.0%.
The average overall survival time (OS) and median survival time (MST) of the
patients treated by chemotherapy (C group) were highest about 14.2 and 9.3 months
(respectively at A group 6.7 and 6.0 months. P