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Sall, D.J., Briggs, S.L., Chirgadze, N.Y., Clawson, D.K., Gifford-Moore, D.S., Klimkowski, V.J., McCowan, J.R., Smith, G.F. and Wikel, J.H. (1998) Dibasic Benzo[b]thiophene Derivatives as a Novel Class of Active Site Directed Thrombin Inhibitors. 2. Exploring Interactions at the Proximal (S2) Binding Site. Bioorganic & Medicinal Chemistry Letters, 8, 2527-2538.
http://dx.doi.org/10.1016/S0960-894X(98)00447-8
has been cited by the following article:
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TITLE:
New Approaches for the Use of Acetoacetanilide in the Synthesis of Thiophenes and Their Fused Derivatives with Anti-Tumor Activity
AUTHORS:
Rafat M. Mohareb, Sherif M. Sherif, Wagnat W. Wardakhan, Amr S. Abouzied
KEYWORDS:
Acetoaceanilide, Thiophene, Anti-Tumor, Docking
JOURNAL NAME:
Open Access Library Journal,
Vol.1 No.8,
November
26,
2014
ABSTRACT: Acetoacetanilide derivatives 1a-c reacted with either malnonitrile or ethyl cyanoacetate and elemental sulfur to give the thiophene derivatives 3a-f. The reactivity of 3a towards some chemical reagents to give thiophene, theino[2,3-b]pyridine, thieno[2,3-c]pyrimidine and coumarin derivatives was studied. The anti-tumor evaluation of the newly synthesized compounds against the three human tumor cells lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) showed that compounds 8a, 8b and 14 exhibit higher inhibitory effects towards the three tumor cell lines than the positive control doxorubicin.