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Article citations


Cai, M., Han, H., Bei, J., Liu, C., Lei, J., Cui, Q., Feng, Q., Wang, H., Zhang, J., Liang, Y., Chen, L., Kang, T. and Shao, J. (2012) Expression of Human Leukocyte Antigen G Is Associated with Prognosis in Nasopharyngeal Carcinoma. International Journal of Biological Sciences, 8, 891-900.

has been cited by the following article:

  • TITLE: Soluble Human Leukocyte Antigen-G Expression in Pregnancy Success and Early Pregnancy Loss in Korle-Bu Teaching Hospital

    AUTHORS: Abdul-Rahman Mubarak, Irene Sitsofe Blebu, Kareem Mumuni, Yao Tettey, Richard Kwasi Gyasi, Andrew Anthony Adjei, Michael Ofori

    KEYWORDS: Soluble Human Leukocyte Antigen G (sHLA-G), Spontaneous Abortion, Maternal Immune Tolerance Implantation

    JOURNAL NAME: Open Journal of Immunology, Vol.6 No.1, March 2, 2016

    ABSTRACT: Introduction: Human leukocyte antigen G (HLA-G) is a non-classical major histocompatibility complex (MHC) class Ib antigen characterized by a limited polymorphism. The expression of HLA-G at immune privileged sites and its ability to inhibit the effectors functions of immune cells has set HLA-G as a molecule of immune tolerance. This expression pattern is unique among HLA genes and suggests that HLA-G may be involved in interactions that are critical in establishing and/or maintaining pregnancy. Methods: Soluble HLA-G (sHLA-G) levels were measured using a BioVendor sHLA-G ELISA kit following the manufacturer’s protocol. The study participants include women undergoing spontaneous abortion, non-pregnant women, males and an archive sample of women who had normal vaginal deliveries without any complications and any history of malaria infection from gestation to delivery. Results: Soluble HLA-G levels were higher among women undergoing spontaneous abortion as compared to women who had normal vaginal delivery and non-pregnant women. Soluble HLA-G levels were also higher in second trimester as compared to first trimester in both women who had spontaneous abortions and women who had normal delivery. Conclusion: Although sHLA-G levels were higher among women undergoing spontaneous abortion as compared to non-pregnant women and women who had normal delivery, this may be playing a role in the maintenance of maternal immune tolerance to fetal antigen, since plasma sHLA-G levels increased with increasing trimester in both women who had normal delivery and women undergoing spontaneous abortion.