TITLE:
Prevalence of Cerebral Atherosclerosis among Patients with Metabolic Syndrome: A Case Control Study on Egyptian Subjects
AUTHORS:
Sherif Elwan, Tarek Zoheir Tawfik, Heba Sayed Assal, Shaimaa El-Jaafary, Montasser Mohamed Hegazy, Salwa Tawfik, Alshaimaa Mahmoud Aboulfotooh, Foad Abd-Allah
KEYWORDS:
Metabolic Syndrome, Preclinical Atherosclerosis, Silent Brain Infarction, Neurovascular Ultrasound, Brain MRI, Egyptian Population
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.6 No.1,
January
27,
2016
ABSTRACT: Background: The metabolic syndrome (MetS) is a clustering of vascular risk factors that tend to increase the risk of occurrence of diabetes mellitus type 2 (DMT2), cardiovascular and cerebro-vascular ischemic events. The aim of the present study is to investigate the association of extra-cranial and intracranial arterial atherosclerosis as well as silent brain infarction (SBI) with MetS, thereby determining the potential cerebrovascular atherosclerotic risk of MetS in the Egyptian population. Methods: A case control study was conducted on 50 Egyptian subjects with MetS and 30 without with age range from 40 - 60 years old. All participants were free from cerebrovascular ischemic events [stroke or transient ischemic attack (TIA)]. All participants underwent complete neurological examination, assessment of the diagnostic criteria for MetS, carotid and transcranial duplex ultrasonography (U/S) and brain MRI. Results: Preclinical carotid atherosclerosis (athero-sclerotic plaques with