TITLE:
Prognostic Clinico-Pathological Features of 99 Cases Advanced Non-Small Cell Lung Cancer—Egyptian National Cancer Institute
AUTHORS:
Hala Aziz Shokralla, Mohamed Rahouma
KEYWORDS:
Non-Small Cell, Lung Cancer, Clinico-Pathological, Prognosis, NCI Egypt
JOURNAL NAME:
Advances in Lung Cancer,
Vol.4 No.3,
January
21,
2016
ABSTRACT: Background: Worldwide, lung cancer is the most commonly diagnosed cancer
and causes more deaths than any other cancer. In Egypt; it accounts for 7% of
male cancer & 3% in females. It is considered to be 3rd most
common cancer in Egyptian males & 6th most common of both sexes.
Materials and Methods: A total of 99 advanced non-small cell lung cancer
patients who underwent first line platinum containing chemotherapy in our
institute were included in this study. All clinical and pathological data were
collected from patient’s files retrospectively between 2012-2014. Results: All
99 cases were diagnosed at late stage IIIB-IV (59 cases were IIIB).The median
age was 54 years (range: 30 - 70) with 53% of cases are ≥ 54 years. 71% were
males with male: female ratio of 2.4:1. All male patients were chronic smokers.
The most frequent symptom was coughing (68%). Most of the patients had primary
lung cancer in the right lung (77%). The most common histological subtype was squamous
cell carcinoma (35.4%) with 54 cases present with PS-I, the remain was PS-II.
All cases received platinum containing chemotherapy. The majority of cases experienced
a progressive disease 60.6%. The median progression free survival (PFS) was 6
months & median overall survival (OS) was 18 months. We found that PS,
disease stage, pathological subtypes and response to treatment statistically
affect both median OS & PFS. Age affects only OS. Conclusions: Our analysis
suggests that some of clinico-pathological factors & response to first line
platinum containing regimens affect both OS & PFS of advanced NSCLC. This
may be beneficial as prognostic markers and further studies were needed to aid
in identification and treatment of these patients.