F.L. Mi, C.Y. Kuan, S.S. Shyu, S.T. Lee and S.F. Chang, “The study of gelation kinetics and chain-relaxation properties of glutaraldehyde-cross-linked chitosan gel and their effects on microspheres preparation and drug release”, Carbohydrate Polymers, Vol.41, No.4, 2000, pp. 389-396.

has been cited by the following article:

• TITLE: Preparation, Characterization and Drug-Release Behaviors of Crosslinked Chitosan/Attapulgite Hybrid Microspheres by a Facile Spray-Drying Technique

  AUTHORS: Qin Wang, Jie Wu, Wenbo Wang, Aiqin Wang

  KEYWORDS: microsphere; chitosan; attapulgite; spray drying; controlled release

  JOURNAL NAME: Journal of Biomaterials and Nanobiotechnology, Vol.2 No.3, May 20, 2011

  ABSTRACT: A series of chitosan/attapulgite (CTS/APT) hybrid microspheres were prepared by a facile spray-drying technique. The developed hybrid microspheres were characterized by Fourier transform infrared spectra (FTIR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and the zeta potential. The encapsulation efficiency and in vitro controlled release properties of the microspheres for drug were evaluated using diclofenac sodium (DS) as a model drug. Results indicated that the introduction of APT into crosslinked CTS microspheres can achieve narrow size distribution and make them more uniform. The isoelectric point of the microspheres increased from 8.14 to 9.18 with increasing the content of APT to 10 wt.%. DS loaded in hybrid microspheres is hardly released in simulated gastric fluid, but quickly released in simulated intestinal fluid. The electrostatic interaction between hybrid microspheres and DS can improve the encapsulation efficiency and controlled release behavior of CTS/APT microspheres, and the release mechanism fits Fickian diffusion.