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Y. H. Lin, F. L. Mi, C. T. Chen, W. C. Chang, S. F. Peng, H. F. Liang and H. W. Sung, “Preparation and Characterization of Nanoparticles Shelled with Chitosan for Oral Insulin Delivery,” Biomacromolecules, Vol. 8, No. 1, 2007, pp. 146–152.

has been cited by the following article:

  • TITLE: Self-Assembled Core-Shell Poly(ethylene glycol)-POSS Nanocarriers for Drug Delivery

    AUTHORS: Kyu-Oh Kim, Byoung-Suhk Kim, Ick-Soo Kim

    KEYWORDS: Self-assembly, Amphiphilic, Nanoparticles, POSS, Insulin, Oral delivery

    JOURNAL NAME: Journal of Biomaterials and Nanobiotechnology, Vol.2 No.3, May 6, 2011

    ABSTRACT: In this work, novel nanostructured core-shell poly(ethylene glycol) (PEG)-polyhedral oligosilsesquioxane (POSS) nanoparticles were used to encapsulate insulin as new drug delivery carriers. The morphologies, particle size and ζ potential of the pure nanostructured core-shell PEG-POSS and the corresponding insulin-loaded PEG-POSS nanoparticles were investigated by transmission electron microscopy (TEM) and laser diffraction particle sizer. TEM analysis demonstrated that pure and insulin-loaded self-assembled PEG-POSS nanoparticles were of spherical shape with core-shell nanostructure, and were well-dispersed and uniform in size distribution. Insulin release test showed that insulin was well-protected inside PEG-POSS nanoparticles at gastric pH for 2hrs, and was released at intestinal pH (pH 6-7) where the absorption and activation of the drug are necessary. We therefore believe that such nanostructured PEG-POSS nanoparticles could be useful as a potential carrier for insulin drug delivery systems.