N. Tzioumaki, S. Manta, E. Tsoukala, J. V. Voorde, S. Liekens, D. Komiotis and J. Balzarini, “Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogues: Novel 5-Fluo- rouracil analogues that target thymidylate synthase,” European Journal of Medicinal Chemistry, Vol. 46, No. 4, 2011, pp. 993-1005.

has been cited by the following article:

• TITLE: Unsaturated Keto and Exomethylene Pyranonucleoside Analogues of Thymine and Uracil Exhibit Potent Antioxidant Properties

  AUTHORS: Chrysoula Spanou, Niki Tzioumaki, Stella Manta, Panagiotis Margaris, Dimitrios Kouretas, Dimitri Komiotis, Kalliopi Liadaki

  KEYWORDS: D-Lyxopyranonucleoside Derivatives, D-Arabinonucleoside Derivatives, DNA Damage, Peroxyl Radicals.

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.2 No.3, July 26, 2011

  ABSTRACT: Nucleoside analogues play an important role in the development of antitumor and antiviral agents. Specific sugar modified pyranonucleosides, like the keto and exocyclic methylene nucleosides, have been studied for their biological properties, but there is little information regarding their antioxidant activity. The present study reports the antioxidant activity of a series of α,β-unsaturated 2’- or 4’ - keto and exomethylene 5’-hydroxymethyl-lacking pyranonucleosides. The antioxidant activity was evaluated using an in vitro assay which is based on the capacity to protect DNA strand scission induced by peroxyl radicals (ROO?). The majority of the tested nucleoside analogues exhibit potent antioxidant properties against ROO? radicals. We conclude that the presence of a carbon-carbon double bond at α,β-disposition to exomethylene group at position 2 of the sugar moiety and the substitution of thymine with uracil improves the antioxidant capacity of these analogues.