TITLE:
Status of ESBL Producing Bacteria Isolated from Skin Wound at a Tertiary Care Hospital in Bangladesh
AUTHORS:
Taslima Yasmin, Md. Abdullah Yusuf, Mohammed Abdun Nur Sayam, Rezwana Haque, Golam Mowla
KEYWORDS:
Extended Spectrum β-Lactamases, Escherichia coli, Klebsiella Species, Gram Negative Bacilli
JOURNAL NAME:
Advances in Infectious Diseases,
Vol.5 No.4,
December
7,
2015
ABSTRACT: Background: ESBL producing
bacteria are increasing with an alarming rate with a wide range of infections.
Objective: The purpose of the present study was to see the status of ESBL producing
bacteria isolated from skin wounds. Methodology: This cross sectional study was
conducted in the Department of Microbiology at Mymensingh Medical College,
Bangladesh from January 2011 to June 2011 for a period of 6 months. All the
patients, at any age with both sexes presented with skin wound infection, were
taken as study population. Wound swab was taken from all patients. Specimens
were processed and bacteria were isolated and identified according to standard
procedure. The ESBL status was confirmed by double disc diffusion test (DDDT)
and minimum inhibitory concentration (MIC) by agar dilution method by standard
procedure according to Clinical Laboratory Standard Institute (CLSI).
Antimicrobial resistance was done by disc diffusion method. Result: A total
number of 84 wound swabs were taken of which the most common ESBL producing
bacteria were Esch. coli (61.5%),Proteus species (78.3%) and Klebsiella species (88.9%). All the isolates were
sensitive to imipenem and nitrofurantoin followed by amikacin (92.9%).
Conclusion: In conclusion, ESBL producing E.
coli is the most common
bacteria causing skin wound infection followed by Proteus species with a reduced sensitivity
towards antibiotics.