TITLE:
Synthesis, Characterization and Biological Screening of Ferulic Acid Derivatives
AUTHORS:
T. Naga Ravi Kiran, Ch. Sri Alekhya, B. V. S. Lokesh, A. V. S. Madhu Latha, Y. Rajendra Prasad, T. Naga Mounika
KEYWORDS:
Ferulic Acid, Cytotoxicity, Hela (Cervical Cancer Cell Lines), A549 (Lung Cancer Cell Lines), HT-29 (Colorectal Cancer Cell Lines), Synthesis
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.10,
September
24,
2015
ABSTRACT: According to WHO, cancer is a leading cause of death worldwide,
accounting for 8.2 million deaths in 2012. Among several factors involved in
the pathogenesis of cancer, free radical formation followed by damage to DNA
and cell protein is one of the causes. Natural plant products have gained
enormous interest in the prevention or treatment of chronic diseases. Ferulic
acid, like other phenolic acids (caffeic acid, sinapic acid) possess anti
cancer activity. A series of ferulic esters (FE1 - FE11) and ferulic amides (FA1 - FA10) were synthesized and evaluated
for their cytotoxic activity.