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http://dx.doi.org/10.1159/000110862

has been cited by the following article:

• TITLE: The Influence of Leukocyte and Platelet Concentrate Enrich in Stem Cells on Bone Regeneration Processes: A Clinical and Flow Cytometry Study

  AUTHORS: Tomasz Bielecki, Krzysztof Wójcik, Tadeusz Bold, Bartłomiej Osadnik, Tomasz Szczepański

  KEYWORDS: Healing, Growth Factors, Induction, Stimulation, Osteogenesis

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.8 No.9, September 24, 2015

  ABSTRACT: This article reports the efficacy of percutaneous autologous leukocyte- and platelet-rich plasma (L-PRP) injection into delayed union site as a minimally invasive method alternative to bone marrow aspirate and open grafting techniques. Each of 15 participants was followed on a regular basis with clinical examinations, roentgenograms. The average time to union was 8.4 weeks after L-PRP injection and the union was achieved in all cases. CD34+/45+ cells counts were increased by 410% and CD34+/45- cells counts were increased by 488% on average in L-PRP. Our investigation showed that L-PRP enrich in stem cells can produce the desired stimulatory response despite a substantial amount of vital bone cells from mesenchymal line. We believe that the using of L-PRP enriched in stem cells, growth factors and antimicrobial proteins might be a promising treatment method in regenerative medicine.