TITLE:
Adiponectin Receptor 1 Single Nucleotide Polymorphism Is Highly Associated with Hypertriglyceridemia in Asian Male—A Novel Genetic Screening to Reduce Risk of Cerebrovascular Disease
AUTHORS:
William C. W. Huang, Rong-Fu Chen, Yu-Ying Yang
KEYWORDS:
ADIPOR1 SNP, Hypertriglyceridemia, Male
JOURNAL NAME:
World Journal of Neuroscience,
Vol.5 No.5,
September
18,
2015
ABSTRACT: Background: Adiponectin is
involved in regulating both glucose and fatty acid. Associations of the known
adiponectin receptors 1 (ADIPOR1) single nucleotide polymorphism (SNP) with
diabetes have been demonstrated while hypertriglyceridemia is frequently
associated with cerebrovascular disease (CVD) among diabetes. Triglyceride
metabolism was also reported to be different between genders and estrogen was
observed to interfere with adiponectin effects via ADIPOR1. It seems important
to investigate whether the ADIPOR1 SNP variants may be significant determinants
in triglyceride metabolism and hence be a risk of CVD in specific gender.
Methods: A survey was performed on random self-reported healthy subjects aged
35 and above with their biochemical data collected. Genotyping for ADIPOR1 SNP
(rs1342387) was carried out usingTaqMan
Genotyping Assays. Interviews were also conducted regarding stress, adverse
diet behavior and exercise. Multivariable logistic regression analyses were
performed to identify the strongest contributing variables. Findings: The
ADIPOR1 minor allele carrier (T/T and T/C) had significantly (p= 0.02) higher TG mean compared to
homozygous (C/C) major alleles. TG difference was significantly higher in male
(p= 0.02) with a larger
difference in mean, whereas the difference disappeared among female (p= 0.32). Multivariate logistic
regression analyses were performed by defining abnormal TG based on NCEP
criteria of metabolic syndrome, and when all life style variables were entered
in the model with ADIPOR1, only the ADIPOR1 inmale showed significant (p= 0.03) and very high association with
abnormal TG (Exp(β) 16.31). Discussion: The findings provide sample
evidence of a relation between ADIPOR1 SNP minor allele carrier and high TG
concentrations in male. The association of abnormal TG and ADIPOR1 is much
stronger than that compared to life style. The implications of this survey may
be further extend to identifying the genetic risk of abnormal TG at young age
and reduce the CVD incidence by early intervention.