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http://dx.doi.org/10.1016/j.jconrel.2013.03.004

has been cited by the following article:

• TITLE: Synthesis of Sulfated Cyclodextrin Amphiphiles with Liposomal Encapsulation Properties

  AUTHORS: Tetsuya Furuike, Koichi Nasu, Hiroshi Tamura

  KEYWORDS: Cyclodextrin, Amphiphile, Liposome, Encapsulation

  JOURNAL NAME: Journal of Encapsulation and Adsorption Sciences, Vol.5 No.3, September 1, 2015

  ABSTRACT: A novel class of amphiphiles with sulfate groups at the C-6 position and palmitoyl groups at the C-2, 3 positions of α-, β-, and γ-cyclodextrin (CD) were efficiently synthesized. These compounds formed stable monolayers with high collapse pressures at the air-water interface. The mixed monolayer behaviors of the 6-O-sulfated CD amphiphiles (SO3-CDC16) in the presence of dipalmitoyl phosphatidylcholine (DPPC) and cholesterol were discussed using the surface pressure-molecular area (π-A) isotherms. The collapse pressures showed maxima at molar ratios of SO3-CDC16 lower than 10 mol%. A morphological analysis of the liposomes containing DPPC and 4 mol% SO3-CDC16 formed in PBS was carried out using transmission electron microscopy with negative staining, and vesicles with maximum diameters of 350-500 nm were observed. Moreover, the releasing ability of these liposomes was examined using a fluorescent compound, calcein. It was clearly shown that liposomes containing SO3-CDC16 could release encapsulated calcein more easily than liposomes consisting only of DPPC, and that the release rate depended on the phase transition temperature of the SO3-CDC16 included in the liposome membrane.