TITLE:
Prognosis of Breast Cancer Patients Underwent Surgery in a Developing Country
AUTHORS:
Bangaly Traore, Abdoulaye Toure, Telly Sy, Mamadou Moustapha Dieng, Mamoudou Condé, Ahmadou Deme, Namory Keita
KEYWORDS:
Breast Cancer, Breast Surgery, Prognosis, Developing Countries
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.9,
August
31,
2015
ABSTRACT: Background: We aim to review different factors associated with the
relapse and the mortality in breast cancer patients in restricted-resource
settings over a five-year period. Method: A retrospective cohort study
including 133 women underwent breast cancer surgery was performed at the
Surgical Oncology Unit of the Conakry University Hospital in Guinea.
Socio-demographical characteristics, clinical information, treatment and data
on relapse and survival were retrieved from medical files. Predictor factors of
relapse were analyzed by using univariate and multivariate logistic regression.
Factors associated with mortality were analyzed by Kaplan Meier survival and
Cox models. Results: Breast cancer surgery was conservative in 13 cases (9.8%)
and radical in 120 cases (90.2%). Five-year relapse was 33.8% ± 8.0% and the
predictor factors of this relapse were age and stage III (p = 0.005). The overall 5-year mortality was 42.1% and the risk
factors independently associated with death were body mass index (p = 0.01), origin of patients (p = 0.02), radiotherapy (p = 0.01) and cancer relapse (p = 0.001). Conclusion: The proportions
of relapse and death were higher in breast cancer patients. The age and the
stage of cancer at the time of surgery were the predictor factors of relapse.
Body mass index, origin of patients, radiotherapy and cancer relapse were
associated with death.