Article citationsMore>>
Rini, B.I., Melichar, B., Ueda, T., Grünwald, V., Fishman, M.N., Arranz, J.A., Bair, A.H., Pithavala, Y.K., Andrews, G.I., Pavlov, D., Kim, S. and Jonasch, E. (2013) Axitinib with or without Dose Titration for First-Line Metastatic Renal-Cell Carcinoma: A Randomised Double-Blind Phase 2 Trial. Lancet Oncology, 14, 1233-1242.
http://dx.doi.org/10.1016/S1470-2045(13)70464-9
has been cited by the following article:
-
TITLE:
Efficacy and Safety of Axitinib as First-Line Therapy in Japanese Patients with Metastatic Renal Cell Carcinoma
AUTHORS:
Takeshi Namekawa, Satoshi Fukasawa, Atsushi Komaru, Masayuki Kobayashi, Takayuki Ohzeki, Yosuke Sato, Junryo Rii, Hirotsugu Uemura, Tomohiko Ichikawa, Takeshi Ueda
KEYWORDS:
Axitinib, Renal Cell Carcinoma, First Line
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.8,
July
28,
2015
ABSTRACT: Previous study
reported that patients treated with axitinib as second-line therapy had longer
median progression-free survival than those treated with sorafenib for
metastatic renal cell carcinoma (mRCC). In this study, we reviewed our
experience of axitinib as a first-line therapy for mRCC in Japanese patients,
focusing on its efficacy and safety. We retrospectively assessed 26 patients
treated with axitinib as a first-line therapy for mRCC from July 2010 to July
2014 at Chiba Cancer Center and Kinki University Hospital. Observation period
was 24.6 ± 18.3 months. The objective response rate was 50.0%, and the median
progression-free survival was 27.5 months. Overall survival was not estimable.
Common grade 3 adverse events were hypertension in 19 patients and proteinuria
in 5 patients. Axitinib demonstrated significant efficacy as a first-line therapy
in Japanese patients with mRCC. Careful monitoring and management of the
adverse effects may help to control its toxicities.
Related Articles:
-
Sandra Steffens, Christoph von Klot, Hendrik Egggers, Christoph Seidel, Gerd Wegener, Mark Schrader, Markus A. Kuczyk, Andres J. Schrader
-
Kazuhiro Murakami, Kazuhiko Yamamoto, Kumiko Aoki, Ikuyo Fukumoto, Tsutomu Sugiura, Tadaaki Kirita
-
Takahito Suyama, Takeshi Ueda, Satoshi Fukasawa, Atsushi Komaru, Masayuki Kobayashi, Yukio Naya, Naoki Nihei, Tomohiko Ichikawa
-
Khaled Ben Ahmed, Amira Daldoul, Ghassen Tlili, Laila Ben Fatma, Olfa Gharbi, Mahdi Afrit, Jihene Fkih, Hammouda Boussen, Mounir Frikha, Faouzi Mosbah, Slim Ben Ahmed
-
Gudmundur Björnsson, Astridur Johannesdottir, Bjarni Valtysson, Gisli H. Sigurdsson