Kallio, A., Scheinin, M., Koulu, M., Ponkilainen, R., Ruskoaho, H., Viinamäki, O. and Scheinin, H. (1989) Effects of Dexmedetomidine, a Selective Alpha 2-Adrenoceptor Agonist, on Hemodynamic Control Mechanisms. Clinical Pharmacology and Therapeutics, 46, 33-42.
http://dx.doi.org/10.1038/clpt.1989.103

has been cited by the following article:

• TITLE: The Effect of Dexmedetomidine on Oxygenation and Intrapulmonary Shunt during One Lung Ventilation

  AUTHORS: Mehmet I. Buget, Zerrin Sungur, Berker Ozkan, Mesut Yornuk, Fatma Demircan, Mert Senturk

  KEYWORDS: Dexmedetomidine, One-Lung Ventilation, Intrapulmonary Shunt

  JOURNAL NAME: Open Journal of Anesthesiology, Vol.5 No.7, July 15, 2015

  ABSTRACT: Background: The effect of intravenously administered dexmedetomidine on oxygenation during one-lung ventilation has not been studied. The hypothesis of this prospective, randomized study was that dexmedetomidine would be associated with an improvement in oxygenation during one-lung ventilation. The secondary outcome was the change in the intrapulmonary shunt. Materials and Methods: Thirty patients undergoing one-lung ventilation were included. Patients in Group D (n = 15) received a bolus dose of 1 μg·kg-1 dexmedetomidine at 10 min after induction of anaesthesia followed by an infusion of 0.4 μg·kg-1·hr-1 that was stopped at the end of the surgery, and those in the control group(Group C, n = 15) were given saline at the same dosage. Vital signs, PaO2, and pulmonary shunting (Qs/Qt) were compared. Results: During one-lung ventilation, the PaO2 in Group D increased significantly and Qs/Qt significantly decreased compared to Group C (PaO2, 203.7 ± 42.3 mmHg vs. 173 ± 37.6 mmHg [P = 0.04] and Qs/Qt 19.8% ± 4.5% vs. 31% ± 2.4% [P