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has been cited by the following article:

• TITLE: Varicose Veins, Retinal Tears and Deep Vein Thrombosis, New Insights into the Causes from Adams Disease

  AUTHORS: James David Adams Jr.

  KEYWORDS: Transient Receptor Potential Cation Channels, Deep Vein Thrombosis, Varicose Veins, Retinal Tears, Adams Disease

  JOURNAL NAME: Open Journal of Apoptosis, Vol.4 No.3, July 10, 2015

  ABSTRACT: Adams disease is the consequence of overly active transient receptor potential cation channels (TRP). This case report presents a patient suffering from multiple vascular problems and may provide new insights into the causes of venous problems. Endothelial and smooth muscle cells in veins contain TRP. These channels when activated excessively result in calcium accumulation, oxygen radical formation and apoptosis of endothelial and smooth muscle cells. The death of critical cells in vein valves, may lead to varicose veins. The loss of endothelial cells in venules may lead to retinal tears. Damage to vein walls may lead to a deep vein thrombosis. Transient receptor potential cation channels may be new drug targets of interest in the treatment or prevention of these conditions.