TITLE:
Comparative Epigenetic Analyses of Acute and Chronic Leukemia
AUTHORS:
Yan Zhang, Dianjing Guo
KEYWORDS:
Leukemia, Epigenetics, Histone Modification, Promoter
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.3 No.6,
June
12,
2015
ABSTRACT:
Comparative analysis of epigenetic
alterations between acute vs. chronic leukemia, with an emphasis on histone modifications,
was conducted. We focus on the promoter regions of the whole genomes as well as
oncogenes. Our results revealed that obvious differential histone modifications
pattern exists between the two subtypes. H3K27ac has a high tag density in the promoter
region in both Dnd41 cell lines and K562 cell lines. H3K27ac and H3K4me1 have high
correlation between the two cell lines of oncogenes. Similar results were also achieved
in the promoter region of high expression genes in the Jurkat and K562 cell lines
based on RNA-seq data. This suggests that H2K27ac and H3K4me1 are active regulators
in leukemia cell lines.