TITLE:
The Effective Catalyst (Cobalt Salt/Lewis Acid) for Beckmann Rearrangement of Cycloalkanone Oximes to Lactams under Mild Conditions
AUTHORS:
Masahiro Komeda, Ayana Ozaki, Keita Hayashi, Michinori Sumimoto, Kenji Hori, Tsunemi Sugimoto, Hidetoshi Yamamoto
KEYWORDS:
Beckmann Rearrangement, Cycloalkanone Oximes, Lactam, Cobalt Catalysts, Lewis Acids
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.5 No.2,
May
25,
2015
ABSTRACT: The Beckmann rearrangement of cyclohexanone oxime was achieved by the combined use of cobalt salt and Lewis acids co-catalysts (each 10 mol%). Various combinations of cobalt salts and Lewis acids gave lactams in a satisfactory yield under mild conditions. This method makes it possible to reduce undesirable byproducts.