TITLE:
Association between Hepato-Biliary Status and HbA1C in Type 2 Diabetes Mellitus with Coronary Artery Disease (CAD)
AUTHORS:
R. Ramesh, N. AdhishwarKumaran, V. KuzhandaiVelu, R. Reeta, M. SathishBabu, G. Niranjan
KEYWORDS:
Bilirubin, Coronary Artery Disease, Type 2 Diabetes Mellitus
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.5 No.2,
May
4,
2015
ABSTRACT: Bilirubin has both antioxidant activity and
cardioprotective potential. Decreased levels are associated with predicting
CAD. Recent studies showed that bilirubin has inverse correlation with
glycemic status. So in this we evaluated the role of Hepatobiliary function
as a marker of predictor CAD in patient with T2DM. Total 100 subjects included
50 T2DM patients with CAD and 50 T2DM without CAD. All the subject venous blood
was collected after overnight fasting for biochemical analysis. After the
statistical analysis, the results showed significant difference between two
groups as follows total bilirubin (0.32 ± 0.15; 0.90 ± 032; p = 0.000), direct
bilirubin, indirect bilirubibn, Total Protein, Albumin, ALT, AST, HbA1c. Our
finding implies that decreased serum bilirubin increases the risk of CAD in
patients with T2DM and it shows inverse correlation between HbA1c and
bilirubin.