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http://dx.doi.org/10.1016/0003-9861(63)90042-0

has been cited by the following article:

• TITLE: Iron Oxide Nanoparticles Induced Oxidative Damage in Peripheral Blood Cells of Rat

  AUTHORS: Usha Singh Gaharwar, Paulraj R

  KEYWORDS: Oxidative Stress, Iron Oxide Nanoparticles, Antioxidant Enzymes, Genotoxicity, Peripheral Blood Cells

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.8 No.4, April 14, 2015

  ABSTRACT: Nanotechnology is a rapidly growing field that has elicited much concern due to a variety of applications in different fields such as industry, medicine, and cosmetics. These developments increase the concern among the general population. Hence, there is an urgent need to explore the possible human health effects of these nanomaterials. The present study is aimed to evaluate the cytotoxic and genotoxic effects of iron oxide nanoparticles (IONPs) in-vivo. In order to study the toxic effects, Wistar rats were administered intravenously with various doses of IONPs (Fe2O3) through caudal vein once in a week for 28 days, and various biochemical assays such as antioxidant enzymes activity (SOD, CAT, and GSH), lipid peroxidation, DNA damage and hematological parameters were evaluated. Genotoxicity was evaluated by comet assay and oxidative stress was measured by anti-oxidant enzymes. The results reveal that IONPs alter hematological factor such as RBC counts, WBC counts, neutrophils, monocytes and hemoglobin. A dose-dependent inhibition (p