Why Us? >>

  • - Open Access
  • - Peer-reviewed
  • - Rapid publication
  • - Lifetime hosting
  • - Free indexing service
  • - Free promotion service
  • - More citations
  • - Search engine friendly

Free SCIRP Newsletters>>

Add your e-mail address to receive free newsletters from SCIRP.

 

Contact Us >>

WhatsApp  +86 18163351462(WhatsApp)
   
Paper Publishing WeChat
Book Publishing WeChat
(or Email:book@scirp.org)

Article citations

More>>

Ursini-Siegel, J., Hardy, W.R., Zuo, D., Lam, S.H., Sanguin-Gendreau, V., Cardiff, R.D., et al. (2008) ShcA Signalling Is Essential for Tumour Progression in Mouse Models of Human Breast Cancer. EMBO Journal, 27, 910-920.
http://dx.doi.org/10.1038/emboj.2008.22

has been cited by the following article:

  • TITLE: Phospho-Tyrosine(s) vs. Phosphatidylinositol Binding in Shc Mediated Integrin Signaling

    AUTHORS: Xiaochen Lin, Olga Vinogradova

    KEYWORDS: Shc, Integrin, Phosphatidylinositol, ITC, NMR

    JOURNAL NAME: American Journal of Molecular Biology, Vol.5 No.2, March 24, 2015

    ABSTRACT: The Shc adaptor protein, particularly its p52 isoform, has been identified as a primary signaling partner for the tyrosine(s)-phosphorylated cytoplasmic tails of activated β3 integrins. Inspired by our recent structure of the Shc PTB domain in complex with a bi-phosphorylated peptide derived from β3 cytoplasmic tail, we have initiated the investigation of Shc interaction with phospholipids of the membrane. We are particularly focused on PtdIns and their effects on Shc mediated integrin signaling in vitro. Here we present thermodynamic profiles and molecular details of the interactions between Shc, integrin, and PtdIns, all of which have been studied by ITC and solution NMR methods. A model of p52 Shc interaction with phosphorylated β3 integrin cytoplasmic tail at the cytosolic face of the plasma membrane is proposed based on these data.