Ali, K.A., Abdalghfar, H.S., Mahmoud, K. and Ragab, E.A. (2013) Synthesis and Antitumor Activity of New Poly-Substituted Thiophenes and 1,3,4-Thiadiazoles Incorporating 2,6-Pyridine Moieties. Journal of Heterocyclic Chemistry, 50, 1157-1164.

has been cited by the following article:

• TITLE: Catalyst Free Synthesis of Pyridine-2,6-bis(2-bromo-propane-1,3-dione) and Pyrdine-2,6-bis(N-arylthiazoline-2-thiones)

  AUTHORS: Korany A. Ali, Mohamed A. Elsayed, Eman Ali Ragab

  KEYWORDS: N-Alkylthiazoline-2-Thiones, Catalyst-Free Reactions, Monobromination, 2, 6-Disubstituted Pyridine

  JOURNAL NAME: Green and Sustainable Chemistry, Vol.5 No.1, February 11, 2015

  ABSTRACT: We have described herein a catalyst-free preparation method of pyridine-2,6-bis(N-alkylthiazoline-2-thiones) (4a-i) by the reaction of primary amines, CS2, and pyridine-2,6-bis(2-bromo-1,3- dicarbonyl) derivatives (2a-c) in water. Also, we have described a catalyst free, green chemistry protocols to monobromination of pyridine-2,6-bis(2-bromo-1,3-dicarbonyl) derivatives with high yield, using NBS as a brominating agent, that led to eco-friendly isolation and purification proce-dures. Furthermore, we have studied the reactivity of pyridine-2,6-bis(2-bromo-1-methyl-pro- pane-1,3-dione) (2a) towards thiourea to afford 2,6-bis(5-benzoyl-2-aminothiazol-4-yl)pyridine (9).