Article citationsMore>>
Newton, P.N., Lee Sue, J., Goodman, C., Fernández Facundo, M., Yeung, S., Phanouvong, S., Kaur, H., Amin, A.A., Whitty, C.J.M., Kokwaro, G.O., Lindegårdh, N., Lukulay, P., White, L.J., Day, N.P.J., Green, M.D. and White, N.J. (2009) Guidelines for Field Surveys of the Quality of Medicines: A Proposal. PloS Medicine, 6, 0252-0257.
has been cited by the following article:
-
TITLE:
Application of Total Error Strategy in Validation of Affordable and Accessible UV-Visible Spectrophotometric Methods for Quality Control of Poor Medicines
AUTHORS:
Jérémie Kindenge Mbinze, Jean Nsangu Mpasi, Elza Maghe, Sébastien Kobo, Rodrigue Mwanda, Guy Mulumba, Jacquie Bolavie Bolande, Trésor Menanzambi Bayebila, Maguy Borive Amani, Philippe Hubert, Roland Djang’eing’a Marini
KEYWORDS:
Poor Quality Medicines, UV-Visible Spectrophotometric Methods, Quinine, Amoxicillin, Metronidazole, Validation, Total Error, Accuracy Profiles
JOURNAL NAME:
American Journal of Analytical Chemistry,
Vol.6 No.2,
January
19,
2015
ABSTRACT: In the framework of fighting against the poor quality medicines sold in developing countries using classical analytical methods easily accessible in those countries, four UV-Visible spectrophotometric methods for one antimalarial (quinine) and two antibiotics (amoxicillin and metronidazole) have been developed and validated according to the total error strategy using the accuracy profiles as a decision tool. The dosing range was 2 - 10 μg/mL (for quinine sulfate in tablet), 4 - 12 μg/mL (for quinine bichlorhydrate in oral drop-metronidazole benzaote in oral suspension) and 15 - 35 μg/mL (for amoxicillin trihydrate in capsule). The validated methods were then applied in determining the content of some analogous medicines sold in the Democratic Republic of Congo. Thus, the proposed UV-Visible spectrophotometric methods are simple and suitable to quantify quinine, amoxicillin and metronidazole in different pharmaceutical forms.
Related Articles:
-
Pedro Pablo Cárdenas Alzate, William Ardila Urueña
-
Xinliang Zhang, Yue Qi, Mingzhe Zhu
-
Lyubov Bakunovich, Mikhail Nilov, Nikolay Sharov, Boris Belashev
-
Casimir Komenan
-
Ananda Prasad Panta, Ram Prasad Ghimire, Dinesh Panthi, Shankar Raj Pant